• CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state 

      Huijgens, Patty Thalia; Heijkoop, Roy; Vanderschuren, Louk; Lesscher, Heidi; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-24)
      This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects ...
    • Changes in reward-induced neural activity upon Cafeteria Diet consumption 

      Heijkoop, Roy; Ferrer Lalanza, Jaume; Solanas, Montserrat; Álvarez-Monell, Adam; Subias-Gusils, Alex; Escorihuela, Rosa; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-01)
      Excessive consumption of highly palatable foods rich in sugar and fat, often referred to as “junk” or “fast” foods, plays a central role in the development of obesity. The highly palatable characteristics of these foods activate hedonic and motivational mechanisms to promote food-seeking behavior and overeating, which is largely regulated by the brain reward system. Excessive junk food consumption ...